1. Design for realistic long-term use
The first principle is honesty about who the home is for. A split-level home is not a suitable long-term residence for someone with mobility limitations. That does not mean it cannot be built; it means the design should be honest about the trade-off.
For a family with active children and healthy adults expecting to live in the home for 15 to 25 years, split-level design is typically fine. The stairs are manageable and the architectural benefits outweigh the accessibility limitations.
For a couple expecting to age in the home for 30 years or more, consider whether split-level is the right choice. If it is (perhaps because the site demands it or the design vision requires it), factor in the accessibility strategies that follow.
For a household including someone with specific mobility needs, single-level design is usually the right answer regardless of block characteristics.